Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …
Th17 cells in central nervous system autoimmunity
C Sie, T Korn, M Mitsdoerffer - Experimental neurology, 2014 - Elsevier
Multiple sclerosis (MS) is the most important autoimmune disease of the central nervous
system (CNS). Its animal model experimental autoimmune encephalomyelitis (EAE) has …
system (CNS). Its animal model experimental autoimmune encephalomyelitis (EAE) has …
Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis
AM McGinley, SC Edwards, M Raverdeau… - Journal of …, 2018 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …
(MS) that shares many features with the human disease. This review will focus on the role of …
Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
HS Domingues, M Mues, H Lassmann, H Wekerle… - PloS one, 2010 - journals.plos.org
Background There is consensus that experimental autoimmune encephalomyelitis (EAE)
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …
Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
A Rostami, B Ciric - Journal of the neurological sciences, 2013 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …
TH17 cytokines in autoimmune neuro-inflammation
B Becher, BM Segal - Current opinion in immunology, 2011 - Elsevier
It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …
Th17 cells in autoimmune demyelinating disease
BM Segal - Seminars in immunopathology, 2010 - Springer
Recently published studies in multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE) have demonstrated an association between the development of …
encephalomyelitis (EAE) have demonstrated an association between the development of …
Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis
RA O'Connor, CT Prendergast, CA Sabatos… - The Journal of …, 2008 - journals.aai.org
It has recently been proposed that experimental autoimmune encephalomyelitis, once
considered the classical Th1 disease, is predominantly Th17 driven. In this study we show …
considered the classical Th1 disease, is predominantly Th17 driven. In this study we show …
The role of TH17 cells in multiple sclerosis: Therapeutic implications
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
A Jäger, V Dardalhon, RA Sobel, E Bettelli… - The Journal of …, 2009 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis
induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the …
induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the …