BACKGROUND AND OBJECTIVE: For purposes of therapeutic decision making, we used
quantitative polymerase chain reaction (PCR) for molecular follow-up of 55 patients with …

The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia
(CML) patients after bone marrow transplantation. It was previously reported that the relapse …

Chronic myeloid leukemia (CML) has become a paradigm in cancer medicine for how
advances in understanding of the biology of the disease can be translated into the …

The reverse transcriptase–polymerase chain reaction (RT-PCR) has become widely used
for monitoring minimal residual disease after allogeneic stem cell transplantation (SCT) for …

PURPOSE Disappearance of the Philadelphia chromosome during treatment for chronic
myeloid leukemia (CML) has become an important therapeutic end point. To determine the …

Bone marrow and/or peripheral blood of patients with chronic myeloid leukemia (CML) was
investigated by the following three parameters: Ph'chromosome, bcr-abl expression in fresh …

We have sought to determine whether peripheral blood or bone marrow is more sensitive for
assessment of minimal residual disease in chronic myeloid leukaemia (CML) …

The polymerase chain reaction (PCR) has become a standard method for highly sensitive
detection of the bcr/abl rearrangement in patients with chronic myelogenous leukemia …

Residual disease remains a major problem in the treatment of human neoplasia. To
effectively monitor minimal leukemic activity after bone marrow transplantation (BMT), we …

Polymerase chain reaction (PCR) is a powerful and rapid method for specifically detecting
BCR–ABL rearrangement by amplification of the complementary DNA (cDNA) produced by …