Monitoring of disease response during treatment with tyrosine kinase inhibitors of patients
with chronic myelogenous leukemia dramatically changed after the introduction of real-time …

We analysed 20 patients with BCR‐ABL‐positive acute lymphoblastic leukaemia (ALL) by
quantitative competitive polymerase chain reaction (QC‐PCR) to study the kinetics of the …

Increasing numbers of patients with chronic myeloid leukaemia (CML) treated with tyrosine
kinase inhibitors achieve undetectable levels of BCR‐ABL mRNA using sensitive …

Previous studies have shown that tumor-specific bcr-abl mRNA can often be detected by
polymerase chain reaction.(PCR) for months to years after allogeneic bone marrow …

We have sought to define the relationship between the proportion of marrow metaphases
showing the Philadelphia chromosome (Ph) and levels of BCR‐ABL mRNA assessed by …

Real-time RT-PCR has great advantages for estimating transcript levels in a variety of
situations. These include relative rapid assay times (hours), reliability and ease of …

A modified two-step polymerase chain reaction (PCR) was used for the amplification of
BCR/ABL mRNA in 16 patients with Philadelphia chromosomepositive (Ph+) chronic …

PURPOSE: To evaluate the usefulness of fluorescence in situ hybridization (FISH) on
peripheral-blood specimens to evaluate the cytogenetic response to treatment in patients …

The BCR/ABL hybrid gene plays a central role in the pathogenesis of the chronic phase of
chronic myeloid leukemia (CML). We used a very sensitive quantitative reverse transcriptase …

The majority of patients with chronic‐phase (CP) chronic myeloid leukemia (CML) who are
treated with Bcr‐Abl tyrosine kinase inhibitors such as imatinib and dasatinib achieve …