We investigated the functions of Akt during vascular development and remodeling by using
an inducible endothelial cell-specific driver of the dominant-active myrAkt. We found that …

The formation of endothelial lumen is fundamental to angiogenesis and essential to the
oxygenation of hypoxic tissues. The molecular mechanism underlying this important process …

The signalling pathways operational in quiescent, post-development vasculature remain
enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Blood vessel recruitment is an important feature of normal tissue growth. Here, we examined
the role of Akt signaling in coordinating angiogenesis with skeletal muscle hypertrophy …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive
vascular network is established during embryogenesis from multipotential mesenchymal …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Background Vascular malformations are clinical disorders in which endothelial cells fail to
remodel and/or undergo programmed cell death, leading to abnormal persistence of blood …

Arterial morphogenesis is an important and poorly understood process. In particular, the
signaling events controlling arterial formation have not been established. We evaluated …