Abstract Angiopoietin 2 (Ang2) expression in the retina is increased during physiologic and
pathologic neovascularization suggesting that it may be involved. In this study, we used …

cAMP-dependent protein kinase A (PKA) is a ubiquitously expressed serine/threonine
kinase that regulates a variety of cellular functions. Here, we demonstrate that endothelial …

The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction
or deregulated blood vessel function contributes to multiple diseases, including diabetic …

Rationale: Coronary artery disease, the direct result of atherosclerosis, is the most common
cause of death in Western societies. Vascular smooth muscle cell (VSMC) apoptosis occurs …

Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible
remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase …

Angiogenesis is the complex process of new blood vessel formation defined by the
sprouting of new blood vessels from a pre-existing vessel network. Angiogenesis plays a …

The vascular system forms as a branching network of endothelial cells that acquire identity
as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene …

Cardiovascular function depends on patent blood vessel formation by endothelial cells
(ECs). However, the mechanisms underlying vascular" tubulogenesis" are only beginning to …

Blood vessels form an important interface between the environment and the organism by
carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is …

Arteriovenous malformations (AVMs) are fragile direct connections between arteries and
veins that arise during times of active angiogenesis. To understand the etiology of AVMs and …