Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian
proteins and can modulate the function of many others. Because of the pleiotropic effects of …

Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or
structural cofactor for many different proteins. Zinc-dependent proteins are found in the …

Genes that are involved in mammalian zinc transport recently have been cloned. These all
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …

Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

Abstract Zinc (Zn2+) is the most abundant trace element in cells and is essential for a vast
number of catalytic, structural, and regulatory processes. Mounting evidence indicates that …

Zinc transport through the systemic circulation can be viewed from many different
perspectives. In the past, attention has been paid to the zinc concentration and zinc-binding …

In addition to its critical role in normal cell function, growth, and metabolism, zinc is
implicated as a major factor in the development and progression of many pathological …

The importance of zinc in cell physiology is related mainly to its intracellular involvement in
enzyme catalysis, protein structure, protein-protein interactions, and protein-oligonucleotide …