Locus coeruleus MRI contrast is associated with cortical thickness in older adults
There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC)
is important for later-life cognition. Less understood is how LC integrity relates to brain …
is important for later-life cognition. Less understood is how LC integrity relates to brain …
[HTML][HTML] In vivo visualization of age-related differences in the locus coeruleus
KY Liu, J Acosta-Cabronero, A Cardenas-Blanco… - Neurobiology of …, 2019 - Elsevier
The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …
nervous system, may play an important role in neuropsychiatric disorders including …
Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences
The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and
behavioral function, may play an important role healthy ageing and in neurodegenerative …
behavioral function, may play an important role healthy ageing and in neurodegenerative …
Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal
aging, but not much is known regarding how these changes manifest in MRI images, or …
aging, but not much is known regarding how these changes manifest in MRI images, or …
Locus coeruleus magnetic resonance imaging in cognitively intact elderly subjects
The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in
neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1 …
neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1 …
Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events
D Hämmerer, MF Callaghan… - Proceedings of the …, 2018 - National Acad Sciences
The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to …
varies considerably across healthy older individuals, and is suggested to contribute to …
Histologic validation of locus coeruleus MRI contrast in post-mortem tissue
The locus coeruleus (LC) noradrenergic system regulates arousal and modulates attention
through its extensive projections across the brain. LC dysfunction has been implicated in a …
through its extensive projections across the brain. LC dysfunction has been implicated in a …
[HTML][HTML] Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal
and attention. Recent studies have examined the microstructural properties of the LC using …
and attention. Recent studies have examined the microstructural properties of the LC using …
[HTML][HTML] Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: an …
Late-life depression (LLD) is a risk factor for age-dependent cognitive deterioration.
Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To …
Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To …
[HTML][HTML] Locus coeruleus connectivity alterations in late-life major depressive disorder during a visual oddball task
I Del Cerro, I Martínez-Zalacaín, A Guinea-Izquierdo… - NeuroImage: Clinical, 2020 - Elsevier
Abstract The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission.
Structural alterations in the LC have been observed in neurodegenerative disorders and at …
Structural alterations in the LC have been observed in neurodegenerative disorders and at …