Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions
and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus …

Dear Editor, Cellular communication is crucial during basic development and in the
maintenance of homeostasis in adult organisms, and such communication involves the …

Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing
significant sequence homology with the invertebrate gap junction proteins, the innexins and …

Pannexins are single-membrane large-pore channels that release ions and ATP upon
activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ …

It is widely recognized that ATP, along with other nucleotides, subserves important
intercellular signalling processes. Among various nucleotide release mechanisms, the …

Gene targeting strategies have become a powerful technology for elucidating mammalian
gene function. The recently generated knockout (KO)-first strategy produces a KO at the …

Abstract Background Pannexins (Panxs) are relatively newly discovered large-pore ion and
metabolite permeable channels. Although no proteomics-based interactome has yet been …

Abstract Pannexin1 (Panx1), a protein related to the gap junction proteins of invertebrates,
forms nonjunctional channels that open upon depolarization and in response to mechanical …

Abstract Pannexin 2 (Panx2) is a large-pore ATP-permeable channel with critical roles in
various physiological processes, such as the inflammatory response, energy production and …

Pannexin channels are newly discovered ATP release channels expressed throughout the
body. Pannexin 1 (Panx1) channels have become of great interest as they appear to …