It is generally accepted that the nervous system contributes to the pathophysiology of
peripheral inflammation, and a neurogenic component has been implicated in many …

Research conducted in the last 10 years has increased our knowledge on pain mechanisms
substantially. Although many local tissue mediators, including neuropeptides, are known to …

Current evidence supports the central role of neuropeptides in the molecular mechanisms
underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell …

The sensory neuropeptides substance P and calcitonin gene-related peptide have been
implicated in the mediation of pulpal inflammation. A possible role in healing following injury …

Dental pulp is a soft mesenchymal tissue densely innervated by afferent (sensory) fibers,
sympathetic fibers, and parasympathetic fibers. This complexity in pulp innervation has …

Since the rôle of neurogenic inflammation in various pathological conditions is well‐
established, we presume that it also has great importance in the development of several …

The aims of the present study were to investigate whether the tachykin‐ins substance P and
neurokinin A were present in gingival crevicular fluid in both periodontal health and disease …

Background: The study of periodontitis provides a unique model for assessing the
involvement of neuropeptides in inflammatory disease. Aim: To investigate the effects of …

Objective: Orthodontic tooth movement causes inflammatory reactions in the periodontal
membrane and dental pulp. It has been reported that substance P (SP) and calcitonin gene …

Substance P has been studied in relation to its distribution within gingival tissues as well as
its effect on cultured human gingival fibroblasts. The tissue distribution was varied …