Chronotherapeutic interventions (CTs) produce rapid antidepressant effects and, when
applied sequentially, maintain an enduring antidepressant response following the initial CT …

Bipolar disorder (BD) is a mood disorder with genetic and neurobiological underpinnings,
characterized primarily by recurrent episodes of mania and depression, with notable …

Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder
arise in part from a malfunction of the circadian system, linking the disease with an abnormal …

When circadian rhythms-the daily oscillations of various physiological and behavioral events
that are controlled by a central timekeeping mechanism-become desynchronized with the …

Among other factors, bipolar disorder is characterized by disturbances in sleep and
biological rhythms that typically cycle over a 24-h, or circadian period. Indeed, almost all of …

Discoveries in the molecular genetics of the circadian clock and the introduction of the
antidepressant agent, agomelatine, with effects on circadian rhythms, have revived interest …

There are two main reasons for the growing interest in the dependence of mood disorders
on the circadian clock and its connected pathways. First, the successful translation of …

Numerous hypotheses have been put forth over the years to explain the development of
bipolar disorder. Of these, circadian rhythm hypotheses have gained much importance of …

BACKGROUND: Electroencephalographic (EEG) sleep slow wave activity (SWA; EEG
power between 0.6 and 4Hz) has been proposed as a marker of central synaptic plasticity …

This chapter reviews prominent neurobiological effects of chronotherapies for the treatment
of mood disorders and integrates previously described therapeutic mechanisms with current …