Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets

ME Vega-Ostertag, SS Pierangeli - Current rheumatology reports, 2007 - Springer
Antiphospholipid antibodies (aPL) are associated with thrombosis and pregnancy loss in
patients with systemic lupus erythematosus and antiphospholipid syndrome. Strong …

Pathogenic role of antiphospholipid antibodies

JE Salmon, PG de Groot - Lupus, 2008 - journals.sagepub.com
The antiphospholipid antibody syndrome (APS) is characterized by recurrent arterial and
venous thrombosis and/or pregnancy in association with antiphospholipid (aPL) antibodies …

Pathophysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome

O Amengual, T Atsumi, T Koike - Current Vascular …, 2011 - ingentaconnect.com
The antiphospholipid syndrome (APS) is an autoimmune disease in which recurrent
vascular thrombosis, pregnancy morbidity or a combination of these events is associated …

New targeted therapies for treatment of thrombosis in antiphospholipid syndrome

SS Pierangeli, ME Vega-Ostertag… - Expert reviews in …, 2007 - cambridge.org
Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss
in antiphospholipid syndrome (APS), a disorder initially characterised in patients with …

The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome

R Willis, EB Gonzalez, AR Brasier - Current Rheumatology Reports, 2015 - Springer
Pathogenic antiphospholipid antibodies (aPL) are the driving factors of recurrent pregnancy
loss and thrombosis that characterize antiphospholipid syndrome (APS). Current evidence …

New insights in the pathophysiology of antiphospholipid syndrome

A Sacharidou, PW Shaul… - Seminars in thrombosis …, 2018 - thieme-connect.com
The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by an
elevated risk for arterial and venous thrombosis and pregnancy-related morbidity. Since the …

Pathophysiology of the antiphospholipid antibody syndrome

R Willis, SS Pierangeli - Autoimmunity highlights, 2011 - Springer
Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and
thrombosis that characterizes the antiphospholipid antibody syndrome (APS). Although the …

Prothrombotic mechanisms based on the impairment of fibrinolysis in the antiphospholipid syndrome

R Forastiero, M Martinuzzo - Lupus, 2008 - journals.sagepub.com
Antiphospholipid syndrome (APS) is a clinical autoimmune disorder characterised by
thrombosis, venous or arterial, and recurrent pregnancy morbidity in association with the …

Pathogenic role of complement in antiphospholipid syndrome and therapeutic implications

F Tedesco, MO Borghi, M Gerosa… - Frontiers in …, 2018 - frontiersin.org
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by
thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) …

Antiphospholipid syndrome: pathogenic mechanisms

G Espinosa, R Cervera, J Font, Y Shoenfeld - Autoimmunity Reviews, 2003 - Elsevier
Despite the strong association between antiphospholipid antibodies (aPL) and thrombosis,
the pathogenic role of aPL in the development of thrombosis has not been fully elucidated …