Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading
cause of morbidity and mortality worldwide. Current immunological mechanisms do not …

Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

The systemic inflammatory response is biologically complex, redundant, and activated by
both infectious and noninfectious triggers. Its manipulation can cause both benefit and harm …

Sepsis is a clinical syndrome that results from a systemic host response to an infection. The
outcome of sepsis is poor, and mortality rates are as high as 30–40%. Sepsis is associated …

Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis with subsequent multiple organ dysfunction is a pronounced systemic inflammatory
response to concealed or known infection and is a leading cause of death in intensive care …

Sepsis is a major health problem. The concept that sepsis mortality is the result of an
uncontrolled hyperinflammatory host response has recently been challenged. It is now …

Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an
increased incidence and prevalence over the last years with a simultaneous decrease in its …

NEW THERAPEUTIC APPROACHES FOR SEPSIS HAVE NOT fared well recently. In
January, Eisai announced that its worldwide phase 3 randomized trial of a novel anti–Toll …