Sepsis syndrome, a systemic response to infection, can beget devastating outcomes even in
previously normal individuals. Recent research in septic patients has led to the discovery …

Sepsis is systemic expression of a generalized activation of the host's innate immunity as a
result of varied types of insults. This expression involves a cellular inflammatory response …

Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic
assault due to underlying infection that involves a combination of interconnected …

The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …

Background Our current understanding of the pathophysiology and management of sepsis is
associated with a lack of progress in clinical trials, which partly reflects insufficient …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Background: Remarkable progress has been made during the last decade in defining the
molecular mechanisms that underlie septic shock. This rapidly expanding field is leading to …

Sepsis is a major health problem all over the world. Despite its existence since the time of
Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in …

BACKGROUND: Sepsis and secondary multiple organ failure in critically ill patients are the
major cause of death, but the pathogenesis of sepsis is not clear, especially the dysfunction …

Severe sepsis is the leading cause of mortality in intensive care units. The limited ability of
current therapies to reduce sepsis mortality rates has fueled research efforts for the …