Summary Background Trials in Italy and Sweden showed high efficacy for three-component
and five-component pertussis vaccines, and poor efficacy for a whole-cell vaccine licensed …

Background Infants aged< 1 year are at highest risk for pertussis-related morbidity and
mortality. In 2012, Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) …

Background Recent studies worldwide have reported increasing numbers of adults
diagnosed with Bordetella pertussis despite receiving childhood vaccinations. This study …

Pertussis, or whooping cough, is an infectious disease that is caused by Bordetella
pertussis, affects all age groups and is vaccine preventable. Recently, an increase in …

Background Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination offers
protection for neonates against clinical pertussis until primary vaccinations, but maternal …

A trial to compare the reactogenicity and immunogenicity of a reduced antigen content
diphtheria–tetanus–acellular pertussis (dTpa) vaccine with diphtheria–tetanus–whole-cell …

Background: The epidemiology of pertussis is changing, with a clear increase in the number
of cases diagnosed in adolescents and adults. This development has spurred studies and …

Objectives. To evaluate the safety and immunogenicity of Biken acellular pertussis vaccine
in combination with diphtheria and tetanus toxoid (Biken DTaP) vaccine administered to …

Background: Due to the resurgence of pertussis, many countries have revised the pertussis
immunization schedules and recommended booster doses of pertussis component vaccine …

Background Because of concern about safety and efficacy, no pertussis vaccine has been
included in the vaccination program in Sweden since 1979. To provide data that might …