Developing Genetically Encoded Optical Tools for Imaging Brain Circuits and Pharmacology

C Dong - 2023 - escholarship.org
The brain is an intricate organ that controls various functions, such as perception, behavior,
mood, and cognition, through interactions between neurons, astrocytes with …

Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo

J Day‐Cooney, R Dalangin, H Zhong… - Journal of …, 2023 - Wiley Online Library
The brain relies on many forms of dynamic activities in individual neurons, from synaptic
transmission to electrical activity and intracellular signaling events. Monitoring these …

Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors

C Dong, Y Zheng, K Long-Iyer… - Annual review of …, 2022 - annualreviews.org
Recent advances in fluorescence imaging permit large-scale recording of neural activity and
dynamics of neurochemical release with unprecedented resolution in behaving animals …

[HTML][HTML] Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators

BL Sabatini, L Tian - Neuron, 2020 - cell.com
The actions of neuromodulation are thought to mediate the ability of the mammalian brain to
dynamically adjust its functional state in response to changes in the environment. Altered …

Real time monitoring of neuromodulators in behaving animals using genetically encoded indicators

GO Mizuno, EK Unger, L Tian - … of In Vivo Monitoring in Real …, 2019 - books.google.com
Behavior is driven by precise spatial and temporal patterns of neural activity. Understanding
how the brain processes these complex patterns requires large-scale recording and …

Imaging voltage and brain chemistry with genetically encoded sensors and modulators

A Pal, L Tian - Current Opinion in Chemical Biology, 2020 - Elsevier
Neurons and glia are functionally organized into circuits and higher-order structures that
allow the precise information processing required for complex behaviors. To better …

Voltage imaging to understand connections and functions of neuronal circuits

SD Antic, RM Empson… - Journal of …, 2016 - journals.physiology.org
Understanding of the cellular mechanisms underlying brain functions such as cognition and
emotions requires monitoring of membrane voltage at the cellular, circuit, and system levels …

[HTML][HTML] Advances in engineering and application of optogenetic indicators for neuroscience

KD Piatkevich, MH Murdock, FV Subach - Applied Sciences, 2019 - mdpi.com
Our ability to investigate the brain is limited by available technologies that can record
biological processes in vivo with suitable spatiotemporal resolution. Advances in …

[HTML][HTML] Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators

M Sakamoto, T Yokoyama - Neuroscience Research, 2024 - Elsevier
Monitoring neural activity in individual neurons is crucial for understanding neural circuits
and brain functions. The emergence of optical imaging technologies has dramatically …

[HTML][HTML] State of the art imaging of neurotransmission in animal models

T Patriarchi, A Beyeler - Journal of neuroscience methods, 2022 - ncbi.nlm.nih.gov
The wide range of nervous system functions underlying animal physiology and behaviors is
ultimately encoded by the coordinated activity of neural cells, chiefly neurons and astrocytes …