Context: It is an efficient strategy to apply inhibition of mast cell degranulation for evaluating
anti-allergic effects of compounds. Previous works confirmed that narirutin had anti–allergic …

Background Rosmarinic acid (RA), a polyphenol from edible-medical Lamiaceae herbs, is
known to possess a variety of pharmacological activity, like anti-inflammatory …

Roxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine
H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this study, we …

Background: Mast cells are considered an attractive therapeutic target for treating allergic
diseases, and the Lyn–FcεRIβ interaction is essential for mast cell activation. This study …

AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1)
and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently …

Mast cells are critical cells that prompt various allergic response-inducing factors,
contributing to allergic diseases. While used as an antibiotic for livestock, there is no study …

Chemokines have chemotactic properties on leukocyte subsets whose modulation plays a
pivotal role in allergic inflammatory processes. Our present study was designed to …

Mast cells (MCs) are important therapeutic targets for allergic diseases. High‐affinity
immunoglobulin E (IgE) Fc receptors (FcεRI) trigger abnormal activation of MCs. Allergic …

Objectives We previously demonstrated that some phenylpropanoids are capable of
inhibiting activated mast cells. This study evaluated the anti-allergic effects of licarin A, a …

Mast cells play a crucial role in the pathogenesis of type 1 allergic reactions by binding to
IgE and allergen complexes and initiating the degranulation process, releasing pro …