Molecular mechanisms of arsenic carcinogenesis

C Huang, Q Ke, M Costa, X Shi - Molecular and cellular biochemistry, 2004 - Springer
Arsenic is a metalloid compound that is widely distributed in the environment. Human
exposure of this compound has been associated with increased cancer incidence. Although …

Oxidative mechanism of arsenic toxicity and carcinogenesis

H Shi, X Shi, KJ Liu - Molecular and cellular biochemistry, 2004 - Springer
Arsenic is a known toxin and carcinogen that is present in industrial settings and in the
environment. The mechanisms of disease initiation and progression are not fully …

Arsenic-induced epigenetic changes in cancer development

WN Saintilnord, Y Fondufe-Mittendorf - Seminars in cancer biology, 2021 - Elsevier
Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …

Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis

C Yang, K Frenkel - Journal of environmental pathology …, 2002 - dl.begellhouse.com
Arsenic is a common environmental and occupational pollutant and a wellknown human
carcinogen that causes cancers in many human organs. The exact molecular mechanisms …

A review on arsenic carcinogenesis: epidemiology, metabolism, genotoxicity and epigenetic changes

Q Zhou, S Xi - Regulatory Toxicology and Pharmacology, 2018 - Elsevier
Long-term exposure to arsenic (inorganic arsenic) is a world-wide environmental health
concern. Arsenic is classified as the Group 1 human carcinogen by the International Agency …

Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?

PP Simeonova, MI Luster - … and oncology: official organ of the …, 2000 - europepmc.org
Environmental and occupational exposure to arsenic is associated with increased risk of
skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic …

New perspectives in arsenic-induced cell signal transduction

Y Qian, V Castranova, X Shi - Journal of inorganic biochemistry, 2003 - Elsevier
Although the carcinogenicity of arsenic has been well established, the underlying molecular
mechanisms have not yet been fully identified. Accumulating evidence indicates that the …

Arsenic: signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity

Y Kumagai, D Sumi - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
Arsenic is a naturally occurring metalloid that causes oxidative stress. Exposure of humans,
experimental animals, and cultured cells to arsenic results in a variety of diverse health …

Genotoxic and epigenetic mechanisms in arsenic carcinogenicity

E Bustaffa, A Stoccoro, F Bianchi, L Migliore - Archives of toxicology, 2014 - Springer
Arsenic is a human carcinogen with weak mutagenic properties that induces tumors through
mechanisms not yet completely understood. People worldwide are exposed to arsenic …

Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites

KT Kitchin - Toxicology and applied pharmacology, 2001 - Elsevier
Recent advances in our knowledge of arsenic carcinogenesis include the development of
rat or mouse models for all human organs in which inorganic arsenic is known to cause …