Maternal lipolytic metabolic disorders result in a lipotoxic microenvironment in the ovarian
follicular fluid (FF) which deteriorates oocyte quality. Although cellular stress response …

STUDY QUESTION Does oocyte maturation under lipolytic conditions have detrimental carry-
over effects on post-hatching embryo development of good-quality blastocysts after transfer …

In brief Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as
abnormalities in offspring. This review provides an update on the contributions of oxidative …

The oocyte may be exposed to several sources of stress during its growth and maturation,
which may lead to reduced fertility. Unfolded protein responses (UPRs) play a central role to …

Post‐ovulatory aging of oocytes results in the progressive loss of fertilization and
developmental competence. This degradation of oocyte quality has been the object of …

Aims: The mechanisms coordinating maturation with an environment-driven metabolic shift,
a critical step in determining the developmental potential of human in vitro maturation (IVM) …

Significance: The precipitous age-related decline in female fertility is intimately associated
with a reduction in both the quantity and quality of the germline (oocytes). Although complex …

In the efforts aimed at improving the quality of in-vitro-matured human oocytes, the dynamic
balance and roles of pro-/antioxidants merit further consideration. In-vitromaturation (IVM) is …

Oxidative stress, a key factor in the aging process, has been increasingly recognized as
playing a critical role in ovarian aging (Yan et al., 2022). The accumulation of reactive …

In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …