Bile acids are steroid acids found in the bile of mammals. The bile acid conjugate
tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of stroke …

Background Bile acids are steroid acids found predominantly in the bile of mammals. The
bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in …

Parkinson's disease (PD) is one of the most common chronic progressive
neurodegenerative diseases that affects both motor and non-motor functions. Bile acids …

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well-known for its roles in
regulation of energy homeostasis and glucose metabolism. Here, we show that mice lacking …

Glycolysis is the metabolic pathway that converts glucose into pyruvate. Central nervous
system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied …

Background Nucleotide-binding oligomerization domain-like receptor pyrin domain-
containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses …

GPBAR1/TGR5 is a novel plasma membrane-bound G protein–coupled bile acid (BA)
receptor. BAs are known to induce the expression of inflammatory cytokines in the liver with …

Abstract Gpbar1 (TGR5), a membrane‐bound bile acid receptor, is well known for its roles in
regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong …

Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are
cholesterol metabolites that can signal through receptors on cells throughout the body …