Implementation of pharmacogenetics in transplantation medicine has not met the
expectations expressed 15 years ago. Numerous studies have reported associations …

Pharmacogenetics is the discipline that translates information on genetic variability into
prediction of the pharmacokinetics and pharmacodynamics effects of drugs. It was hoped …

One of the main tasks in the management of organ transplantation is the optimization of
immunosuppressive therapy, in order to provide therapeutic efficacy limiting drug-related …

Tailoring of immunosuppressive drug therapy to the specific requirements of the individual
patient to optimize efficacy and minimize toxicity remains one of the biggest challenges in …

In association with therapeutic drug monitoring of immunosuppressive drugs,
pharmacogenetics has rapidly emerged as an additional tool to refine dose selection or …

With the advent of new immunosuppressants and formulations, the elucidation of molecular
targets and the evolution of therapeutic drug monitoring, the field of organ transplantation …

Most of the immunosuppressants used in organ transplantation are characterized by a
narrow therapeutic index, whereby underdosing is associated with increased risk of …

Different patients receiving the same dose of a drug can exhibit a wide range of blood
concentrations. This is a main concern regarding the immunosuppressive drugs because of …

The transplantation literature includes numerous papers that report associations between
polymorphisms in genes encoding metabolizing enzymes and drug transporters, and …

The immunosuppressive drugs used in organ transplantation typically have a narrow
therapeutic index, with wide variation in the blood concentration achieved from a given dose …