Microorganisms use genetic circuits to integrate environmental information. We have
constructed a synthetic AND gate in the bacterium Escherichia coli that integrates …

The vast majority of experimental data have been accumulated on the transcription
regulation of individual genes within a single model prokaryote, Escherichia coli, which form …

We constructed a library of synthetic promoters for Lactococcus lactis in which the known
consensus sequences were kept constant while the sequences of the separating spacers …

When bacterial cells experience starvation caused by limited availability of amino acids or
by exhaustion of their primary carbon source, they halt further growth and make a rapid …

Bacterial gene expression depends not only on specific regulatory mechanisms, but also on
bacterial growth, because important global parameters such as the abundance of RNA …

Highlights•Cues from environmental bacteria influence the development of many marine
eukaryotes.•The molecular cues produced by environmental bacteria are structurally …

SUMMARY A major challenge for microbiologists is to elucidate the strategies deployed by
microorganisms to adapt to and thrive in highly complex and dynamic environments. In vitro …

For many regulators of bacterial biodegradation pathways, small molecule/effector binding is
the signal for triggering transcriptional activation. Thus, regulation results from a cross-talk …

▪ Abstract The ability to simultaneously monitor expression of all genes in any bacterium
whose genome has been sequenced has only recently become available. This requires not …

Two-component systems that link environmental signals to cellular responses are viewed as
the primary mode of signal transduction in prokaryotes. By analyzing information encoded …