Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species
(ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis …

Proliferation and apoptosis of endothelial cells are crucial angiogenic processes that
contribute to carcinogenesis and tumor progression. Emerging evidence implicates the …

Both Ras and Nox represent ancient gene families which control a broad range of cellular
responses. Both families mediate signals governing motility, differentiation, and proliferation …

The generation of reactive oxygen species (ROS) is required for proper cell signaling, but
must be tightly regulated to minimize deleterious oxidizing effects. Activation of the NADPH …

The superoxide generating enzyme NADPH oxidase has received much attention as a
major cause of oxidative stress underlying vascular disease. However, there is increasing …

NADPH oxidases (Nox) represent a family of hetero-oligomeric enzymes whose exclusive
biological function is the generation of reactive oxygen species (ROS). Nox-derived ROS are …

Vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS) play critical
roles in vascular pathophysiology and in hematological malignancies. VEGF is supposed to …

Reactive oxygen species (ROS) are generally recognized as major products in the cells that
are produced during oxygen utilization, cellular breakdown, and the incomplete degradation …

The reactive oxygen-generating enzyme Nox1 transforms NIH 3T3 cells, rendering them
highly tumorigenic and, as shown herein, also increases tumorigenicity of DU-145 prostate …

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and
survival, events critically involved in angiogenesis. Different isoforms of ROS-generating …