Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells
J Chen, Y Wang, W Zhang, D Zhao, L Zhang… - … and Targeted Therapy, 2020 - nature.com
Reactive oxygen species (ROS) localized at the precise subcellular compartments are
essential for regulating the activity of signaling proteins. Furthermore, ROS are master …
essential for regulating the activity of signaling proteins. Furthermore, ROS are master …
Regulation of pleiotropic physiological roles of nitric oxide signaling
L Soundararajan, A Dharmarajan, P Samji - Cellular signalling, 2023 - Elsevier
Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …
Compartmentalization of redox signaling through NADPH oxidase–derived ROS
M Ushio-Fukai - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen species (ROS) are generated in response to growth factors, cytokines, G
protein–coupled receptor agonists, or shear stress, and function as signaling molecules in …
protein–coupled receptor agonists, or shear stress, and function as signaling molecules in …
Nox proteins in signal transduction
DI Brown, KK Griendling - Free Radical Biology and Medicine, 2009 - Elsevier
The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
NADPH oxidases are essential for macrophage differentiation
NADPH oxidases (NOXs) are involved in inflammation, angiogenesis, tumor growth, and
osteoclast differentiation. However, the role of NOX1 and NOX2 in macrophage …
osteoclast differentiation. However, the role of NOX1 and NOX2 in macrophage …
NADPH oxidases in vascular pathology
A Konior, A Schramm… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …
Targeting extracellular ROS signaling of tumor cells
G Bauer - Anticancer research, 2014 - ar.iiarjournals.org
Expression of membrane-associated NADPH oxidase (NOX1) represents a characteristic
feature of malignant cells. NOX1-derived extracellular superoxide anions are the basis for …
feature of malignant cells. NOX1-derived extracellular superoxide anions are the basis for …
Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …
ROS production in normal cells is controlled by the appropriate regulation between the silver …
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
GM Bokoch, B Diebold, JS Kim… - Antioxidants & redox …, 2009 - liebertpub.com
The NADPH oxidase (Nox) enzyme family generates reactive oxygen species (ROS) that
contribute to cell signaling, innate immune responses, proliferation, and transcription. The …
contribute to cell signaling, innate immune responses, proliferation, and transcription. The …
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …
ROS are typically produced under physiological conditions and play crucial roles in living …