Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells

J Chen, Y Wang, W Zhang, D Zhao, L Zhang… - … and Targeted Therapy, 2020 - nature.com
Reactive oxygen species (ROS) localized at the precise subcellular compartments are
essential for regulating the activity of signaling proteins. Furthermore, ROS are master …

Regulation of pleiotropic physiological roles of nitric oxide signaling

L Soundararajan, A Dharmarajan, P Samji - Cellular signalling, 2023 - Elsevier
Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …

Compartmentalization of redox signaling through NADPH oxidase–derived ROS

M Ushio-Fukai - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen species (ROS) are generated in response to growth factors, cytokines, G
protein–coupled receptor agonists, or shear stress, and function as signaling molecules in …

Nox proteins in signal transduction

DI Brown, KK Griendling - Free Radical Biology and Medicine, 2009 - Elsevier
The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …

NADPH oxidases are essential for macrophage differentiation

Q Xu, S Choksi, J Qu, J Jang, M Choe, B Banfi… - Journal of Biological …, 2016 - ASBMB
NADPH oxidases (NOXs) are involved in inflammation, angiogenesis, tumor growth, and
osteoclast differentiation. However, the role of NOX1 and NOX2 in macrophage …

NADPH oxidases in vascular pathology

A Konior, A Schramm… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

Targeting extracellular ROS signaling of tumor cells

G Bauer - Anticancer research, 2014 - ar.iiarjournals.org
Expression of membrane-associated NADPH oxidase (NOX1) represents a characteristic
feature of malignant cells. NOX1-derived extracellular superoxide anions are the basis for …

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases

GM Bokoch, B Diebold, JS Kim… - Antioxidants & redox …, 2009 - liebertpub.com
The NADPH oxidase (Nox) enzyme family generates reactive oxygen species (ROS) that
contribute to cell signaling, innate immune responses, proliferation, and transcription. The …

Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

HS Tuli, J Kaur, K Vashishth, K Sak, U Sharma… - Archives of …, 2023 - Springer
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …