Forkhead box O transcription factors (FOXOs) regulate several signaling pathways and play
crucial roles in health and disease. FOXOs are key regulators of the expression of genes …

NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS) in the cardiovascular system. Of the 7 members of the Nox family, at least …

NAD (P) H oxidases (Nox) generate reactive oxygen species (ROS) that function in host
defense and cellular signaling. While analyzing the expression of Nox4 at the protein and …

To facilitate functional investigation of the role of NADPH oxidase 1 (NOX1) and associated
reactive oxygen species in cancer cell signaling, we report herein the development and …

The discovery of superoxide-generating enzymes homologues of phagocytic NAD (P) H
oxidase, the Nox family, has led to the concept that reactive oxygen species (ROS) are …

Malignant melanoma cells spontaneously generate reactive oxygen species (ROS) that
promote constitutive activation of the transcription factor nuclear factor-κB (NF-κB). Although …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

Reactive oxygen species (ROS) are considered to be chemically reactive with and
damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to …

NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive
oxygen species (ROS), which have been implicated in several physiological and …

NADPH oxidases are important sources of reactive oxygen species (ROS) which act as
signaling molecules in the regulation of protein expression, cell proliferation, differentiation …