A decade of rapid method development has begun to yield exciting insights into the 3D
architecture of the metazoan genome and the roles it may play in regulating transcription …

Understanding how complex cell-fate decisions emerge at the molecular level is a key
challenge in developmental biology. Despite remarkable progress in decoding the …

One of the most fundamental questions in developmental biology is how one fertilized cell
can give rise to a fully mature organism and how gene regulation governs this process …

Recent burst of new technologies that allow for quantitatively delineating chromatin structure
has greatly expanded our understanding of how the genome is organized in the three …

The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …

Since the advent of the chromosome conformation capture technology, our understanding of
the human genome 3D organization has grown rapidly and we now know that human …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The spatial organization of the genome is essential for the precise control of gene
expression. Recent advances in sequencing and imaging technologies allow us to explore …

Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …