Cytokines maintain intestinal health, but precise intercellular communication networks
remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and …

Innate immune responses are regulated in the intestine to prevent excessive inflammation.
Here we show that a subset of mouse colonic macrophages constitutively produce the anti …

Abstract Polymorphisms of interleukin (IL)-23R and signaling components are associated
with several autoimmune diseases, including inflammatory bowel diseases (IBD). Similar to …

Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility.
Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell …

IL-23 regulation is a central event in the pathogenesis of the inflammatory bowel diseases.
We demonstrate that IFN-γ has anti-inflammatory properties in the initiation phase of IL-23 …

A plethora of functional and genetic studies have suggested a key role for the IL-23 pathway
in chronic intestinal inflammation. Currently, pathogenic actions of IL-23 have been ascribed …

Summary Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and
sensed by most hematopoietic cells. Genome-wide association studies and experimental …

Abstract The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target
for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T …

IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium
sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up …

Abstract Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important …