Pharmacological treatment of idiopathic pulmonary fibrosis: an update

P Spagnolo, AU Wells, HR Collard - Drug Discovery Today, 2015 - Elsevier
Highlights•Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no cure.•A
number of clinical trials of potential treatments have recently been completed.•Pirfenidone …

Pharmacological treatment of idiopathic pulmonary fibrosis: current approaches, unsolved issues, and future perspectives

M Kreuter, F Bonella, M Wijsenbeek… - BioMed research …, 2015 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a devastating condition with a 5‐year survival of
approximately 20%. The disease primarily occurs in elderly patients. IPF is a highly …

Pharmacological management of IPF

R Borie, A Justet, G Beltramo, ED Manali… - …, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a deadly disease with a median survival of
approximately three years in historical cohorts. Despite increased knowledge of disease …

Pharmacotherapy for idiopathic pulmonary fibrosis: current landscape and future potential

G Raghu - European Respiratory Review, 2017 - Eur Respiratory Soc
Over the past two and a half decades, many clinical trials have been designed to determine
the safety and efficacy of pharmacotherapy for patients with idiopathic pulmonary fibrosis …

Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years

G Raghu - European Respiratory Journal, 2017 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. A major
breakthrough in treatment came when, after decades of clinical trials which failed to identify …

Current and future idiopathic pulmonary fibrosis therapy

L Richeldi, F Baldi, G Pasciuto, F Macagno… - The American Journal of …, 2019 - Elsevier
The last years have led to advances in the therapeutic management of idiopathic pulmonary
fibrosis (IPF), mainly through the discovery of new pathological pathways and drugs and …

Current and novel drug therapies for idiopathic pulmonary fibrosis

HI Adamali, TM Maher - Drug Design, Development and Therapy, 2012 - Taylor & Francis
Over the past decade, there has been a cohesive effort from patients, physicians, clinical
and basic scientists, and the pharmaceutical industry to find definitive treatments for …

Advances in the treatment of idiopathic pulmonary fibrosis

A Sergew, KK Brown - Expert Opinion on Emerging Drugs, 2015 - Taylor & Francis
Introduction: Idiopathic pulmonary fibrosis (IPF) is a lung limited, progressive fibrotic disease
with a poor prognosis. The cause is unknown, and currently there is no treatment that …

Pulmonary fibrosis, part II: state-of-the-art patient management

KC Meyer - Expert Review of Respiratory Medicine, 2017 - Taylor & Francis
Introduction: While many pharmacologic therapies for the treatment of idiopathic pulmonary
fibrosis (IPF) have been evaluated via randomized, placebo-controlled clinical trials (RCTs) …

Practical considerations in the pharmacologic treatment of idiopathic pulmonary fibrosis

CS King, SD Nathan - Current opinion in pulmonary medicine, 2015 - journals.lww.com
Currently many questions remain regarding the use of pirfenidone and nintedanib in IPF,
including which drug to prescribe, the optimal patient population to treat, the duration of …