Polarized angular dependent spectroscopy of epithelial cells and epithelial cell nuclei to determine the size scale of scattering structures

JR Mourant, TM Johnson, S Carpenter… - Journal of …, 2002 - spiedigitallibrary.org
An understanding of the relationship between tissue structures and light scattering from
tissue will help facilitate the development and acceptance of noninvasive optical diagnostics …

Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics

JR Mourant, JP Freyer, AH Hielscher, AA Eick… - Applied …, 1998 - opg.optica.org
We have studied the optical properties of mammalian cell suspensions to provide a
mechanistic basis for interpreting the optical properties of tissues in vivo. Measurements of …

Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology

K Sokolov, R Drezek, K Gossage… - Optics …, 1999 - opg.optica.org
We present a method for selective detection of size-dependent scattering characteristics of
epithelial cells in vivo based on polarized illumination and polarization sensitive detection of …

Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ

V Backman, R Gurjar, K Badizadegan… - IEEE Journal of …, 1999 - ieeexplore.ieee.org
We report an in situ method of probing the structure of living epithelial cells, based on light
scattering spectroscopy with polarized light. The method makes it possible to distinguish …

Fiber optic probe for polarized reflectance spectroscopy in vivo: Design and performance

A Myakov, L Nieman, L Wicky… - … of biomedical optics, 2002 - spiedigitallibrary.org
We present the design and construction of a fiber optic probe for elastic light scattering
spectroscopy in vivo with polarized excitation and polarization sensitive detection. The …

Anisotropy of light propagation in biological tissue

A Kienle, FK Forster, R Hibst - Optics letters, 2004 - opg.optica.org
We investigated the propagation of light in biological tissues that have aligned cylindrical
microstructures (eg, muscle, skin, bone, tooth). Because of pronounced anisotropic light …

Characterizing mammalian cells and cell phantoms by polarized backscattering fiber-optic measurements

JR Mourant, TM Johnson, JP Freyer - Applied Optics, 2001 - opg.optica.org
Fiber-optic, polarized elastic-scattering spectroscopy techniques are implemented and
demonstrated as a method for determining both scatterer size and concentration in highly …

Microscopic imaging and spectroscopy with scattered light

NN Boustany, SA Boppart… - Annual review of …, 2010 - annualreviews.org
Optical contrast based on elastic scattering interactions between light and matter can be
used to probe cellular structure, cellular dynamics, and image tissue architecture. The …

Angular dependent light scattering from multicellular spheroids

JR Mourant, TM Johnson, V Doddi… - Journal of Biomedical …, 2002 - spiedigitallibrary.org
We demonstrate that the effects of cell–cell contact and of changes in cell shape have only a
minor effect on the angular distribution of light scattering from mammalian fibroblast cells …

Optical properties of tissues quantified by Fourier-transform light scattering

H Ding, F Nguyen, SA Boppart, G Popescu - Optics letters, 2009 - opg.optica.org
We employ Fourier-transform light scattering, a technique recently developed in our
laboratory, to study the scattering properties of rat organ tissues. Using the knowledge of the …