Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the
oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 …
oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 …
Interferon alpha in combination with GM‐CSF induces the differentiation of leukaemic antigen‐presenting cells that have the capacity to stimulate a specific anti …
X Chen, S Regn, S Raffegerst, HJ Kolb… - British journal of …, 2000 - Wiley Online Library
Although interferon α (IFN‐α) is able to induce haematological remission in 60–80% of
patients with chronic myeloid leukaemia (CML) in early chronic phase, major cytogenetic …
patients with chronic myeloid leukaemia (CML) in early chronic phase, major cytogenetic …
Leukemia stem cells in a genetically defined murine model of blast-crisis CML
SJ Neering, T Bushnell, S Sozer… - Blood, The Journal …, 2007 - ashpublications.org
Myeloid leukemia arises from leukemia stem cells (LSCs), which are resistant to standard
chemotherapy agents and likely to be a major cause of drug-resistant disease and relapse …
chemotherapy agents and likely to be a major cause of drug-resistant disease and relapse …
Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues
BS Hanna, PM Roessner, H Yazdanparast, D Colomer… - Leukemia, 2019 - nature.com
Chronic lymphocytic leukemia (CLL) is associated with substantial alterations in T-cell
composition and function. However, the role of T-cells in CLL remains largely controversial …
composition and function. However, the role of T-cells in CLL remains largely controversial …
IFN-α promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after …
L Gabriele, P Borghi, C Rozera, P Sestili, M Andreotti… - Blood, 2004 - ashpublications.org
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising
from the clonal expansion of a stem cell expressing the bcr/abl oncogene. CML patients …
from the clonal expansion of a stem cell expressing the bcr/abl oncogene. CML patients …
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells
CI Kobayashi, K Takubo, H Kobayashi… - Blood, The Journal …, 2014 - ashpublications.org
Just as normal stem cells require niche cells for survival, leukemia-initiating cells (LICs) may
also require niche cells for their maintenance. Chronic myeloid leukemia (CML) is caused by …
also require niche cells for their maintenance. Chronic myeloid leukemia (CML) is caused by …
Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer
K Schmidt, S Zilio, JC Schmollinger… - Blood, The Journal …, 2013 - ashpublications.org
Tumors frequently induce immature myeloid cells (iMC), which suppress specific and
unrelated cytotoxic T lymphocyte (CTL) responses and are termed myeloid-derived …
unrelated cytotoxic T lymphocyte (CTL) responses and are termed myeloid-derived …
Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells
C Riether, T Gschwend, AL Huguenin, CM Schürch… - Leukemia, 2015 - nature.com
In chronic myelogenous leukemia (CML), quiescent, selfrenewing leukemia stem cells
(LSCs) are resistant against chemotherapy and specific tyrosine kinase inhibitors (TKIs). 1, 2 …
(LSCs) are resistant against chemotherapy and specific tyrosine kinase inhibitors (TKIs). 1, 2 …
[HTML][HTML] Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells
M Hinterbrandner, V Rubino, C Stoll, S Forster… - JCI insight, 2021 - ncbi.nlm.nih.gov
Leukemia stem cells (LSCs) promote the disease and seem resistant to therapy and immune
control. Why LSCs are selectively resistant against elimination by CD8+ cytotoxic T cells …
control. Why LSCs are selectively resistant against elimination by CD8+ cytotoxic T cells …
Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
O Herrmann, MK Kuepper, M Bütow, IG Costa… - BMC cancer, 2019 - Springer
Abstract Background Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause
chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular …
chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular …