Type 2 diabetes is characterized by high concentrations of glucose in the blood, which is
caused by decreased secretion of insulin from the pancreas and decreased insulin action …

Background: Type 2 diabetes mellitus (T2DM) has been a great burden to the world and it is
urgent to develop new treatment strategies. Recently, many targets are currently available to …

Diabetes constitutes an increasing threat to human health, particularly in newly
industrialized and densely populated countries. Type 1 and type 2 diabetes arise from …

Background: Diabetes mellitus (DM) is a disease of systemic metabolic disorders caused by
the decrease of secretion or sensitivity of insulin. In recent years, the study of insulin-related …

Background: Type-2 diabetes mellitus accounts for 80-90% of diabetic patients. So far, the
treatment of diabetes mainly aims at elevating insulin level and lowering glucose level in the …

Despite a rapid increase in the number of drugs available to treat hyperglycemia there
remain several unmet needs in the prevention and treatment of diabetes. There have also …

Abstract Type 2 diabetes (T2DM) is a chronic metabolic disorder. Impaired insulin secretion,
enhanced hepatic glucose production, and suppressed peripheral glucose use are the main …

In Brief Impaired insulin secretion, increased hepatic glucose production, and decreased
peripheral glucose utilization are the core defects responsible for the development and …

Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and
peripheral resistance and is the most prevalent metabolic and endocrine disorder. However …

Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its
prevalence is projected to increase by> 50% globally by 2045. Currently, 10 classes of …