The folate receptor: what does it promise in tissue-targeted therapeutics?
MDA Salazar, M Ratnam - Cancer and Metastasis Reviews, 2007 - Springer
For over a decade the folate receptor has been intensively investigated as a means for
tumor-specific delivery of a broad range of experimental therapies including several …
tumor-specific delivery of a broad range of experimental therapies including several …
Exploitation of the folate receptor in the management of cancer and inflammatory disease
CP Leamon, AL Jackman - Vitamins & Hormones, 2008 - Elsevier
Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
The folate receptor as a rational therapeutic target for personalized cancer treatment
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
Folate-targeted drug strategies for the treatment of cancer.
CP Leamon - Current opinion in investigational drugs (London …, 2008 - europepmc.org
Increasing evidence suggests that the folate receptor (FR) can be exploited for therapeutic
applications. This endocytosing protein is well known to functionally mediate the cellular …
applications. This endocytosing protein is well known to functionally mediate the cellular …
Folate-targeted chemotherapy
The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
Exploiting the folate receptor α in oncology
Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …
successful development of drugs targeting intracellular folate metabolism, such as …
Targeted drug delivery via folate receptors
Targeted delivery via selective cellular markers can potentially increase the efficacy and
reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl …
reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl …
Clinical translation of folate receptor-targeted therapeutics
L Teng, J Xie, L Teng, RJ Lee - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Folate receptor− α (FR− α) has been established as a membrane marker for
ovarian cancer. In addition, it is frequently overexpressed in other major types of epithelial …
ovarian cancer. In addition, it is frequently overexpressed in other major types of epithelial …
Targeting therapeutic and imaging agents to folate receptor positive tumors
JA Reddy, VM Allagadda… - Current pharmaceutical …, 2005 - ingentaconnect.com
The membrane-bound folate receptor (FR) is overexpressed on a wide range of human
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …
Folate receptor-positive gynecological cancer cells: in vitro and in vivo characterization
The folate receptor alpha (FR) is expressed in a variety of gynecological cancer types. It has
been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic …
been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic …