Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Several structural and cellular changes, including marked glial anomalies, have been
observed in association with major depressive disorder. Here we review these cellular …

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …

The present paper reviews astrocyte pathology in major depressive disorder (MDD) and
proposes that reductions in astrocytes and related markers are key features in the pathology …

Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …

Post-mortem histopathological studies report on reduced glial cell numbers in various
frontolimbic areas of depressed patients implying that glial loss together with abnormal …

Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

Mood disorders have multiple phenotypes and complex underlying biological mechanisms
and, as such, there are no effective therapeutic strategies. A review of recent work on the …