Gene therapy is defined as a technology that aims to modify the genetic component of cells
to gain therapeutic benefits. Suicide gene therapy (or gene-directed enzyme prodrug …

Gene therapy of cancer offers the possibility of a targeted treatment that destroys tumors and
metastases, but not normal tissues. In gene-directed enzyme prodrug therapy (GDEPT), or …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

GDEPT, a form of suicide gene therapy, aims to maximize the effect of a toxic drug and
minimize its systemic effects by generating the drug in situ within the tumor. In the first step in …

Enzyme/prodrug gene therapy is a widely used approach in human gene therapy, with its
use in 1996, involving about 1 0% of the patients undergoing clinical trials (Marcel and …

Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …

The use of enzyme/prodrug system has gained attention because it could help improve the
efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells …

Cancer is a disease of high incidence for which conventional treatments are not necessarily
effective. There is a need for the development of new alternative strategies. Among them …

Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial
gene, which allows the conversion of a non-toxic compound into a lethal drug. Although …

Gene-directed enzyme prodrug therapy (GDEPT) has been investigated as a means of
cancer treatment without affecting normal tissues. This system is based on the delivery of a …