Spina bifida is among the phenotypes of the larger condition known as neural tube defects
(NTDs). It is the most common central nervous system malformation compatible with life and …

Hope Northrup, MD, and Kelly A. Volcik~ eural tube defects (NTDs) are the most common
severely disabling birth defects in the United States, with a frequency of approximately 1 of …

Purpose: Neural tube defects (NTDs), including spina bifida and anencephaly, are common
congenital malformations that occur when the neural tube fails to achieve proper closure …

Clues regarding candidate genes which influence susceptibility to spina bifida and
anencephaly come from the identification of folate-associated risk factors and from studies of …

Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000
births, yet the mechanisms by which they arise are unknown. There have been consistent …

Background Neural tube defects (NTDs) are debilitating birth defects involving the central
nervous system (CNS). Despite recent advances, NTDs represent the second most common …

Neural tube defects (NTD), including anencephaly and spina bifida, are a group of severe
congenital abnormalities in which the future brain and/or spinal cord fail to close. In mice …

Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …

Neural tube defects (NTD) remain a major cause of morbidity in spite of the reduction in
liveborn incidence with periconceptional folic acid. However, the etiology remains unknown …