Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets

F Biasi, G Leonarduzzi, PI Oteiza… - Antioxidants & redox …, 2013 - liebertpub.com
Oxidative stress is thought to play a key role in the development of intestinal damage in
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence

H Zhu, YR Li - Experimental Biology and Medicine, 2012 - journals.sagepub.com
Inflammatory bowel disease (IBD) comprises primarily the chronic relapsing inflammatory
disorders, Crohn's disease and ulcerative colitis, with the former affecting any part of the …

[HTML][HTML] Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

AR Bourgonje, D Kloska, A Grochot-Przęczek… - Redox Biology, 2023 - Elsevier
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

DK Sahoo, RM Heilmann, B Paital, A Patel… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Control and dysregulation of redox signalling in the gastrointestinal tract

EL Campbell, SP Colgan - Nature Reviews Gastroenterology & …, 2019 - nature.com
Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …

Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies

T Tian, Z Wang, J Zhang - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Antioxidant therapy in inflammatory bowel diseases

K Dziąbowska-Grabias, M Sztanke, P Zając… - Antioxidants, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the
digestive tract, the etiology of which remains unclear to this day. IBD result in significant …

[HTML][HTML] Antioxidant therapy for treatment of inflammatory bowel disease: does it work?

FA Moura, KQ de Andrade, JCF Dos Santos… - Redox biology, 2015 - Elsevier
Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals
and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon …

Oxidative stress, inflammation, gut dysbiosis: what can polyphenols do in inflammatory bowel disease?

L Li, P Peng, N Ding, W Jia, C Huang, Y Tang - Antioxidants, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal
inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated …