Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

J Fernández-Tajes, A Soto-Hermida… - Annals of the …, 2014 - ard.bmj.com
Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

[PDF][PDF] Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

MD Rushton, LN Reynard, MJ Barter… - Arthritis & …, 2014 - Wiley Online Library
Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage

O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …

E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …

Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

DNA methylome signature in rheumatoid arthritis

K Nakano, JW Whitaker, DL Boyle, W Wang… - Annals of the …, 2013 - ard.bmj.com
Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications

A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

W Den Hollander, YFM Ramos, SD Bos… - Annals of the …, 2014 - ard.bmj.com
Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

[HTML][HTML] Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis

Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Osteoarthritis and …, 2016 - Elsevier
Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …