Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

Orexins (also called hypocretins) have been shown to be importantly involved in reward and
addiction, but little is known about the circuitry that regulates orexin neuronal activity during …

BACKGROUND: The lateral hypothalamic neuropeptide orexin (or hypocretin) is implicated
in drug addiction. Although a role for orexin has been shown in reward and dependence, the …

In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

The orexins (or hypocretins) are hypothalamic neuropeptides that have been implicated in a
variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal …

Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in
addiction and relapse. We examined the role of the orexin system in cocaine-seeking …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

The orexin/hypocretin system is involved in multiple cocaine addiction processes that
involve drug‐associated environmental cues, including cue‐induced reinstatement of …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …