Applications of liquid chromatography-mass spectrometry in drug metabolite identification

LI Liang, C Xiao-yan, Z Da-fang - Journal of Chinese Mass …, 2017 - zpxb.xml-journal.net
Drug metabolism study is an integral part of drug discovery and development. Quick and
accurate identification of the metabolites that formed in the biological matrix is crucial for the …

[HTML][HTML] An Integrated Strategy for Global Qualitative and Quantitative Profiling of Traditional Chinese Medicine Formulas: Baoyuan Decoction as a Case

X Ma, X Guo, Y Song, L Qiao, W Wang, M Zhao, P Tu… - Scientific Reports, 2016 - nature.com
Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs)
is a challenge due to the variety of structures and the complexity of plant matrices. Herein …

Global detection and identification of components from crude and processed traditional Chinese medicine by liquid chromatography connected with hybrid ion trap …

G Cao, C Zhang, Y Zhang, X Cong… - Journal of separation …, 2011 - Wiley Online Library
We herein present a chemical profiling method to efficiently process the information
acquired by ultra fast liquid chromatography (UFLC)‐electrospray ionization source in …

[HTML][HTML] Metabolomics deciphering therapeutic effects and mechanism of traditional chinese medicines

WW Ma, AH Zhang, H Sun, XC Meng… - World Journal of …, 2016 - journals.lww.com
Traditional Chinese medicine (TCM), an ancient medical system, has the advantages of
multi-targeting and multi-ingredient preparations, and is different from modern …

Screening and identification of multi-component in Qingkailing injection using combination of liquid chromatography/time-of-flight mass spectrometry and liquid …

HY Zhang, P Hu, GA Luo, QL Liang, YL Wang… - Analytica chimica …, 2006 - Elsevier
An approach for screening and identification of multi-component in complex traditional
Chinese medicine systems with a combinative LC/MS (MSn) technique was described in this …

Sample preparation for analyzing traditional Chinese medicines

F Tang, Q Zhang, Z Nie, S Yao, B Chen - TrAC Trends in Analytical …, 2009 - Elsevier
One of the biggest challenges in analyzing traditional Chinese medicines (TCMs) is the
complexity of the sample matrices. Sample preparation plays an important role in meeting …

Application of chromatography technology in the separation of active components from nature derived drugs

HY Zhao, JG Jiang - Mini Reviews in Medicinal Chemistry, 2010 - ingentaconnect.com
Chromatography technology has been widely applied in various aspects of the pharmacy
research on traditional Chinese medicine (TCM). This paper reviews literatures, published in …

[HTML][HTML] Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS

D Kang, Q Ding, Y Xu, X Yin, H Guo, T Yu… - Journal of …, 2020 - Elsevier
Identification of components and metabolites of traditional Chinese medicines (TCMs)
employing liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF …

[引用][C] Cell membrane chromatography and its application in the analysis of bioactive ingredients of TCMs

XX Yang, YL Zhang, XX Zhang, XN Li - Journal of Chinese Pharmaceutical Sciences, 2011

High-resolution mass spectrometry-based data acquisition and data-mining technologies for detecting and characterizing drug metabolites and traditional Chinese …

T Cai, C Wu, Q Ruan, S Ma, M Zhu - Identification and quantification of …, 2020 - Elsevier
In the past 20 years, several novel data-mining methods, inclining mass defect filtering,
background subtraction, isotope pattern filtering, and metabolomics analysis, have been …