Schizophrenia is a heterogenous and severe neuropsychiatric disorder that affects nearly
1% of the population worldwide. Antipsychotic drugs are the mainstay of treatment, but not …

Clozapine is often referred to as the gold standard for the treatment of schizophrenia and yet
has also been described as the most underutilized treatment for schizophrenia supported by …

Synopsis Clozapine is an atypical antipsychotic agent whose mode of action is thought to
pertain to its interactions with dopamine and serotonin (5-hydroxytryptamine) …

Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic
effects are probably mediated by dopaminergic and serotonergic activity. Although it …

Clozapine (CLOZ) is an atypical antipsychotic drug being used with increasing frequency
throughout the world and has recently been commercially marketed in the United States. Its …

Schizophrenia is a devastating illness that affects up to 1% of the population; it is
characterized by a combination of positive symptoms, negative symptoms, and cognitive …

Clozapine (Clozaril) represents the first major advance in the pharmacological treatment of
schizophrenia since the introduction of antipsychotics into clinical practice in the 1950s …

Synopsis Clozapine, an antipsychotic agent of the dibenzodiazepine class, is characterised
by relatively weak central dopaminergic activity and displays atypical pharmacological and …

Having challenged the established view that extrapyramidal symptoms are an intrinsic
feature of antipsychotic activity, clozapine was developed as the first atypical antipsychotic …

The advent of antipsychotic drugs represented a milestone in psychotherapeutics. Despite
their proven efficacy, antipsychotic drugs are limited by side effects and treatment resistance …