Due to their eukaryotic heritage, the differences between a fungal pathogen's molecular
makeup and its human host are small. Therefore, the discovery and subsequent …

Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …

In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …

Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

Promising new compounds have recently been identified in an effort to supplement the
relatively sparse portfolio of antifungal drugs. Many of these compounds have defined …

Since the 1950s, antifungal drug discovery has identified three classes of natural products
(griseofulvin, polyenes and echinocandins) and four classes of synthetic chemicals …

Invasive fungal infections are a serious threat to public health, particularly to people with
compromised or suppressed immunity. Although the current antifungal therapies have been …

Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …

Fungal infections represent an increasing threat to a growing number of immune-and
medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a …

Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …