Novel agents and drug targets to meet the challenges of resistant fungi
MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …
Antifungal drug resistance: an emergent health threat
A Vitiello, F Ferrara, M Boccellino, A Ponzo, C Cimmino… - Biomedicines, 2023 - mdpi.com
Fungal infections, named mycosis, can cause severe invasive and systemic diseases that
can even lead to death. In recent years, epidemiological data have recorded an increase in …
can even lead to death. In recent years, epidemiological data have recorded an increase in …
Augmenting azoles with drug synergy to expand the antifungal toolbox
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …
Emerging targets for the development of novel antifungal therapeutics
AH Groll, AJ De Lucca, TJ Walsh - Trends in Microbiology, 1998 - cell.com
Invasive mycoses have become important causes of morbidity and mortality in
immunocompromised patients. New approaches for antifungal therapy are required to meet …
immunocompromised patients. New approaches for antifungal therapy are required to meet …
Fifty years of drug discovery from fungi
AH Aly, A Debbab, P Proksch - Fungal Diversity, 2011 - Springer
For the past 50 years, fungal secondary metabolites have revolutionized medicine yielding
blockbuster drugs and drug leads of enormous therapeutic and agricultural potential. Since …
blockbuster drugs and drug leads of enormous therapeutic and agricultural potential. Since …
Phytochemicals and their antifungal potential against pathogenic yeasts
C de Andrade Monteiro… - Phytochemicals in human …, 2019 - books.google.com
The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly
understood. Among fungi, Candida species are a major cause of morbidity and mortality …
understood. Among fungi, Candida species are a major cause of morbidity and mortality …
Emerging antifungal targets and strategies
M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …
a significant healthcare burden. There is an emerging need for the development of novel …
Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations
SK Pitman, RH Drew, JR Perfect - Expert opinion on emerging …, 2011 - Taylor & Francis
Introduction: Morbidity and mortality associated with invasive fungal infections (IFIs) remains
unacceptably high. Such diseases represent a substantial burden to the healthcare system …
unacceptably high. Such diseases represent a substantial burden to the healthcare system …
Overview of bioactive fungal secondary metabolites: cytotoxic and antimicrobial compounds
R Conrado, TC Gomes, GSC Roque, AO De Souza - Antibiotics, 2022 - mdpi.com
Microorganisms are known as important sources of natural compounds that have been
studied and applied for different purposes in distinct areas. Specifically, in the …
studied and applied for different purposes in distinct areas. Specifically, in the …
Investigational antifungal agents
EJ Ernst - … : The Journal of Human Pharmacology and Drug …, 2001 - Wiley Online Library
Several new antifungal agents, including novel compounds in familiar classes and entirely
new classes targeting previously untapped mechanisms, are in various stages of the drug …
new classes targeting previously untapped mechanisms, are in various stages of the drug …