Efficient maintenance of memory CD8 T cells is central to long-term protective immunity. IL-7–
and IL-15–driven homeostatic proliferation is essential for long-term memory CD8 T cell …

Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T
cell activation. Pathogen-specific T cells in chronically infected hosts are often …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

Heightened protection from infectious disease as conferred by vaccination or pathogen
exposure relies on the effective generation and preservation of specific immunological …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

CD4 T cell responses are crucial to prevent and control viral infection; however, virus-
specific CD4 T cell activity is considered to be rapidly lost during many persistent viral …

During infection, CD8+ T cells not only respond to antigenic signals through their T cell
receptor (TCR) but also incorporate inflammatory signals from cytokines produced in the …