The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway,
essential for cellular communication, orchestrates a myriad of physiological and pathological …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

ABSTRACT According to the World Health Organization (WHO), cancer is the second-
highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the …

Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a
common signaling pathway used to transduce signals from the extracellular to the …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

Cancer is a leading cause of death worldwide. The Janus kinase (JAK) signal transducer
and activator of transcription (STAT) signalling pathway are activated abnormally, which …

Inflammation is at the forefront of carcinogenesis, tumor progression and resistance to
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …