Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …