Rapid noninvasive optical imaging of tissue composition in breast tumor margins

LG Wilke, JQ Brown, TM Bydlon, SA Kennedy… - The American Journal of …, 2009 - Elsevier
BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can
require re-excision. Our objective is to develop an optically based technology which can …

Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins

TM Bydlon, SA Kennedy, LM Richards, JQ Brown… - Optics express, 2010 - opg.optica.org
As many as 20-70% of patients undergoing breast conserving surgery require repeat
surgeries due to a close or positive surgical margin diagnosed post-operatively [1]. Currently …

Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast

S Kennedy, J Geradts, T Bydlon, JQ Brown… - Breast Cancer …, 2010 - Springer
Introduction Residual cancer following breast conserving surgery increases the risk of local
recurrence and mortality. Margin assessment presents an unmet clinical need. Breast tissue …

Intraoperative evaluation of breast tumor margins with optical coherence tomography

FT Nguyen, AM Zysk, EJ Chaney, JG Kotynek… - Cancer research, 2009 - AACR
As breast cancer screening rates increase, smaller and more numerous lesions are being
identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean …

Advancing optical imaging for breast margin assessment: an analysis of excisional time, cautery, and patent blue dye on underlying sources of contrast

TM Bydlon, WT Barry, SA Kennedy, JQ Brown… - PloS one, 2012 - journals.plos.org
Breast conserving surgery (BCS) is a recommended treatment for breast cancer patients
where the goal is to remove the tumor and a surrounding rim of normal tissue. Unfortunately …

Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins

JQ Brown, TM Bydlon, SA Kennedy, ML Caldwell… - PloS one, 2013 - journals.plos.org
We demonstrate a strategy to “sense” the micro-morphology of a breast tumor margin over a
wide field of view by creating quantitative hyperspectral maps of the tissue optical properties …

Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis

MD Keller, SK Majumder, MC Kelley… - Lasers in Surgery …, 2010 - Wiley Online Library
Abstract Background and Objective Most women with early stage breast cancer have the
option of breast conserving therapy, which involves a partial mastectomy for removal of the …

Review of methods for intraoperative margin detection for breast conserving surgery

BW Maloney, DM McClatchy, BW Pogue… - … of biomedical optics, 2018 - spiedigitallibrary.org
Breast conserving surgery (BCS) is an effective treatment for early-stage cancers as long as
the margins of the resected tissue are free of disease according to consensus guidelines for …

Assessment of breast cancer surgical margins with multimodal optical microscopy: A feasibility clinical study

MT Scimone, S Krishnamurthy, G Maguluri, D Preda… - Plos one, 2021 - journals.plos.org
Providing surgical margin information during breast cancer surgery is crucial for the success
of the procedure. The margin is defined as the distance from the tumor to the cut surface of …

Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries

LL De Boer, BG Molenkamp, TM Bydlon… - Breast cancer research …, 2015 - Springer
Recognition of the tumor during breast-conserving surgery (BCS) can be very difficult and
currently a robust method of margin assessment for the surgical setting is not available. As a …