Effect of lipids and lipoproteins on hematopoietic cell metabolism and commitment in atherosclerosis

A Baragetti, F Bonacina, AL Catapano… - …, 2021 - journals.lww.com
Hematopoiesis is the process that leads to multiple leukocyte lineage generation within the
bone marrow. This process is maintained through-out life thanks to a nonstochastic division …

Hypercholesterolemia links hematopoiesis with atherosclerosis

O Soehnlein, FK Swirski - Trends in Endocrinology & Metabolism, 2013 - cell.com
Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …

Cellular metabolism changes in atherosclerosis and the impact of comorbidities

Y Dai, CVC Junho, L Schieren… - Frontiers in Cell and …, 2024 - frontiersin.org
Cell activation and nutrient dysregulation are common consequences of atherosclerosis and
its preceding risk factors, such as hypertension, dyslipidemia, and diabetes. These diseases …

Hematopoiesis and cardiovascular disease

WC Poller, M Nahrendorf, FK Swirski - Circulation research, 2020 - Am Heart Assoc
A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis

F Bonacina, L Da Dalt, AL Catapano… - Molecular aspects of …, 2021 - Elsevier
Metabolic reprogramming is a physiological cellular adaptation to intracellular and
extracellular stimuli that couples to cell polarization and function in multiple cellular subsets …

Metabolism of innate immune cells: impact on atherosclerosis

NP Riksen, R Stienstra - Current Opinion in Lipidology, 2018 - journals.lww.com
Metabolism of innate immune cells: impact on atherosclerosis : Current Opinion in Lipidology
Metabolism of innate immune cells: impact on atherosclerosis : Current Opinion in Lipidology …

Lifestyle effects on hematopoiesis and atherosclerosis

M Nahrendorf, FK Swirski - Circulation research, 2015 - Am Heart Assoc
Diet, exercise, stress, and sleep are receiving attention as environmental modifiers of
chronic inflammatory diseases, including atherosclerosis, the culprit condition of myocardial …

Cholesterol efflux pathways regulate myelopoiesis: a potential link to altered macrophage function in atherosclerosis

AJ Murphy, D Dragoljevic, AR Tall - Frontiers in immunology, 2014 - frontiersin.org
Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …

Hypercholesterolemia tunes hematopoietic stem/progenitor cells for inflammation and atherosclerosis

X Ma, Y Feng - International Journal of Molecular Sciences, 2016 - mdpi.com
As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a
chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD …

Contribution of extramedullary hematopoiesis to atherosclerosis. The spleen as a neglected hub of inflammatory cells

V Fernández-García, S González-Ramos… - Frontiers in …, 2020 - frontiersin.org
Cardiovascular diseases (CVDs) incidence is becoming higher. This fact is promoted by
metabolic disorders such as obesity, and aging. Atherosclerosis is the underlying cause of …