Targeted antimicrobial therapy in the microbiome era

VN Stone, P Xu - Molecular oral microbiology, 2017 - Wiley Online Library
Even though the oral microbiome is one of the most complex sites on the body it is an
excellent model for narrow‐spectrum antimicrobial therapy. Current research indicates that …

Advances in novel therapeutic approaches for periodontal diseases

MM Haque, K Yerex, A Kelekis-Cholakis, K Duan - BMC Oral Health, 2022 - Springer
Periodontal diseases are pathological processes resulting from infections and inflammation
affecting the periodontium or the tissue surrounding and supporting the teeth. Pathogenic …

[HTML][HTML] Porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line

KY How, KP Song, KG Chan - Frontiers in microbiology, 2016 - frontiersin.org
Periodontal disease represents a group of oral inflammatory infections initiated by oral
pathogens which exist as a complex biofilms on the tooth surface and cause destruction to …

Porphyromonas gingivalis survival skills: Immune evasion

S Zheng, S Yu, X Fan, Y Zhang, Y Sun… - Journal of …, 2021 - Wiley Online Library
Periodontitis is a chronic inflammatory condition that destroys the tooth‐supporting tissues
and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis …

In Vitro and In Vivo Activity of Peptidomimetic Compounds That Target the Periodontal Pathogen Porphyromonas gingivalis

J Tan, PC Patil, FA Luzzio… - Antimicrobial agents and …, 2018 - Am Soc Microbiol
The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci
is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a …

Porphyrin-linked nitroimidazole antibiotics targeting Porphyromonas gingivalis

BCM Yap, GL Simpkins, CA Collyer, N Hunter… - Organic & …, 2009 - pubs.rsc.org
Periodontal disease is an inflammatory process affecting supporting tissues surrounding the
teeth. The anaerobic Gram-negative bacterium Porphyromonas gingivalis is implicated in …

Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis

SA Dingsdag, BCM Yap, N Hunter… - Organic & biomolecular …, 2015 - pubs.rsc.org
The periodontal pathogen Porphyromonas gingivalis requires porphyrin supplementation for
growth. Previously, in order to inhibit P. gingivalis growth, we synthesised very effective …

Advances in periodontal pathogens

IG Sufaru, MA Martu, SM Solomon - Microorganisms, 2022 - mdpi.com
Even though periodontitis is considered an infectious disease, there are a number of factors
that distinguish it from other infectious diseases: it is not the result of infection with an …

Identification of interspecies interactions affecting Porphyromonas gingivalis virulence phenotypes

EL Tenorio, BA Klein, WS Cheung… - Journal of Oral …, 2011 - Taylor & Francis
Background: Periodontitis is recognized as a complex polymicrobial disease, however, the
impact of the bacterial interactions among the 700–1,000 different species of the oral …

Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview

J Mysak, S Podzimek, P Sommerova… - Journal of …, 2014 - Wiley Online Library
Porphyromonas gingivalis is a Gram‐negative oral anaerobe that is involved in the
pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in …