Role of OmpA2 surface regions of Porphyromonas gingivalis in host–pathogen interactions with oral epithelial cells

KL Naylor, M Widziolek, S Hunt, M Conolly… - …, 2017 - Wiley Online Library
Outer membrane protein A (OmpA) is a key outer membrane protein found in Gram‐negative
bacteria that contributes to several crucial processes in bacterial virulence. In …

RETRACTED ARTICLE: Temporal activation of anti-and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas …

S Urnowey, T Ansai, V Bitko, K Nakayama… - BMC microbiology, 2006 - Springer
Background Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in
humans. However, the mechanisms of bacterial invasion and the resultant destruction of the …

Porphyromonas gingivalis downregulates the immune response of fibroblasts

E Palm, H Khalaf, T Bengtsson - BMC microbiology, 2013 - Springer
Background Porphyromonas gingivalis is a key pathogen in periodontitis, an inflammatory
disease leading to destruction of bone and tooth-supporting tissue. P. gingivalis possesses …

Porphyromonas Gingivalis and Dextran Sulfate Sodium Induce Periodontitis Through the Disruption of Physical Barriers in Mice

YS Choi, YC Kim, AR Jo, S Ji, KT Koo… - European journal of …, 2013 - journals.sagepub.com
Periodontitis is a chronic inflammatory disease caused by the interaction of plaque-
associated bacteria with host cells. Gingival epithelial barriers provide the first line of …

Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis

C Zenobia, G Hajishengallis - Virulence, 2015 - Taylor & Francis
The oral bacterium Porphyromonas gingivalis has special nutrient requirements due to its
asaccharolytic nature subsisting on small peptides cleaved from host proteins. Using …

Immune evasion strategies of Porphyromonas gingivalis

G Hajishengallis - Journal of oral biosciences, 2011 - Elsevier
Porphyromonas gingivalis is strongly correlated with chronic periodontitis. Its chronic
persistence in the periodontium depends on its ability to evade host immunity without …

Possible role of Porphyromonas gingivalis in orodigestive cancers

I Olsen, Ö Yilmaz - Journal of oral microbiology, 2019 - Taylor & Francis
There is increasing evidence for an association between periodontitis/tooth loss and oral,
gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by …

Modulatory Mechanisms of Pathogenicity in Porphyromonas gingivalis and Other Periodontal Pathobionts

S Sharaf, K Hijazi - Microorganisms, 2022 - mdpi.com
The pathogenesis of periodontitis depends on a sustained feedback loop where bacterial
virulence factors and immune responses both contribute to inflammation and tissue …

Probiotics and metabolites regulate the oral and gut microbiome composition as host modulation agents in periodontitis: A narrative review

FA Deandra, K Ketherin, R Rachmasari, B Sulijaya… - Heliyon, 2023 - cell.com
Periodontitis is defined as an oral bacterial dysbiosis-induced persistent inflammation on
dental supporting tissue resulting in periodontal tissue breakdown and alveolar bone …

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

S Jia, X Li, Q Du - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that
plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of …