We agree with Drs Achtman and Suerbaum that the high frequency of recombination plays a
major role in increasing polymorphism in Helicobacter pylori. However, it is obvious that …

Homologous recombination is one of the key mechanisms responsible for the repair of DNA
double-strand breaks. Recombinational repair normally requires a battery of proteins, each …

Summary Skin, ears, eyes, vagina, mouth, and gastrointestinal mucosa are colonized with
diverse microbial communities of bacteria, archaea, fungi, protozoa, and helminths. We …

Helicobacter pylori is one of the most common bacteria worldwide, estimated to infect half of
the human population. The infection is usually established in childhood and persists for a …

Mammalian cells infected with Helicobacter pylori show an accumulation of DNA double-
strand breaks (DSBs). Previous studies have shown that the virulence factor CagA of H …

Although thousands of DNA damaging events occur in each cell every day, efficient DNA
repair pathways have evolved to counteract them. The DNA repair machinery plays a key …

ABSTRACT Orthologs of RecG and RuvABC are highly conserved among prokaryotes; in
Escherichia coli, they participate in independent pathways that branch migrate Holliday …

The first part of this chapter gives a general background on mutagenesis, discusses how the
appearance of spontaneous mutations within the chromosome of Helicobacter pylori is …

Microorganisms that persist in single hosts face particular challenges. Helicobacter pylori,
an obligate bacterial parasite of the human stomach, has evolved a lifestyle that features …

The gastric pathogen Helicobacter pylori is one of the most genetically diverse bacteria.
Recombination and DNA transfer contribute to its genetic variability and enhance host …