Living dangerously: how Helicobacter pylori survives in the human stomach

C Montecucco, R Rappuoli - Nature Reviews Molecular Cell Biology, 2001 - nature.com
Helicobacter pylori was already present in the stomach of primitive humans as they left
Africa and spread through the world. Today, it still chronically infects more than 50% of the …

Helicobacter pylori AddAB helicase‐nuclease and RecA promote recombination‐related DNA repair and survival during stomach colonization

SK Amundsen, J Fero, LM Hansen… - Molecular …, 2008 - Wiley Online Library
Helicobacter pylori colonization of the human stomach is characterized by profound disease‐
causing inflammation. Bacterial proteins that detoxify reactive oxygen species or recognize …

Plastic cells and populations: DNA substrate characteristics in Helicobacter pylori transformation define a flexible but conservative system for genomic variation

SM Levine, EA Lin, W Emara, J Kang… - The FASEB …, 2007 - Wiley Online Library
Helicobacter pylori, bacteria that colonize the human gastric mucosa, are naturally
competent for transformation by exogenous DNA, and show a panmic‐tic population …

Helicobacter pylori's Unconventional Role in Health and Disease

MS Dorer, S Talarico, NR Salama - PLoS pathogens, 2009 - journals.plos.org
The discovery of a bacterium, Helicobacter pylori, that is resident in the human stomach and
causes chronic disease (peptic ulcer and gastric cancer) was radical on many levels …

ComB proteins expression levels determine Helicobacter pylori competence capacity

C Corbinais, A Mathieu, PP Damke, T Kortulewski… - Scientific reports, 2017 - nature.com
Helicobacter pylori chronically colonises half of the world's human population and is the
main cause of ulcers and gastric cancers. Its prevalence and the increase in antibiotic …

Complete genome sequence of Helicobacter pylori B128 7.13 and a single‐step method for the generation of unmarked mutations

EM Dawson, KA Dunne, EJ Richardson… - …, 2019 - Wiley Online Library
Background Helicobacter pylori represents an interesting model of bacterial pathogenesis
given that most infections are asymptomatic, while a minority of infections cause severe …

[HTML][HTML] Helicobacter pylori: Emergence of a Superbug

A Talebi Bezmin Abadi - Frontiers in Medicine, 2014 - frontiersin.org
It has been shown thatHelicobacter pylori is highly genetically heterogeneous. A
chromosome containing approximately 1,550 genes resulted in a mutant bacterial strain that …

Ten years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent …

H De Reuse, S Bereswill - FEMS Immunology & Medical …, 2007 - academic.oup.com
In this review, we summarize how genomic approaches contributed to the understanding of
the biology of the recently discovered pathogen Helicobacter pylori. Comparative genomics …

Genetic and phenotype changes following in vitro interactions between Helicobacter pylori strains

J Yakoob, X Fan, G Hu, Z Zhang - Journal of gastroenterology …, 2004 - Wiley Online Library
Background: The purpose of the present paper was to determine whether in vitro interaction
between different Helicobacter pylori strains leads to changes in antibiotic susceptibility …

The role of persistence in Helicobacter pylori pathogenesis

DA Israel, RM Peek Jr - Current opinion in gastroenterology, 2006 - journals.lww.com
H. pylori persists in its acidic gastric niche, typically for the lifetime of the host. This
persistence increases the risk of diseases such as peptic ulcer disease and gastric cancer …